The More Profit from Nitrogen Program (MPfN) has been a five-year partnership, commencing in 2016, between Australia’s four most intensive users of nitrogenous fertilisers: cotton, dairy, sugar and horticulture. Comprehensive research and development was conducted to increase nitrogen use efficiency (NUE) across the four sectors whilst improving profitable and sustainable use. By better understanding the influence of contributing factors upon NUE in farming systems, MPfN has generated greater knowledge and understanding of: 
- the interplay of factors to optimise N formulation, rate and timing across industries, farming regions and irrigated/ non-irrigated situations;
 - the contribution (quantifying rate and timing) of mineralisation to crop or pasture N budgets; and
 - how enhanced efficiency fertiliser (EEF) formulations can better match a crop or pasture’s specific N requirements.
 
Research and extension activities were supported by $5.889 million funding from the Australian Government Department of Agriculture, Fisheries and Forestry (then Department of Agriculture, Water and the Environment) as a part of its Rural R&D for Profit program, with a further $9.757 million cash and in-kind contribution from the partnering RDCs, research organisations and collaborating partners.
MPfN was managed by CRDC, in partnership with Dairy Australia, SRA and Hort Innovation. The eleven research projects were delivered by nine lead research organisations:
- NSW Department of Primary Industries (NSW DPI)
 - University of Southern Queensland – Centre for Engineering in Agriculture (USQ)
 - Queensland University of Technology (QUT)
 - The University of Melbourne (UoM)
 - Queensland Government – Department of Environment and Science (DES)
 - Queensland Government – Department of Agriculture and Fisheries (DAF)
 - Northern Territory Government – Department of Industry, Tourism and Trade (NT DITT)
 - University of Tasmania – Tasmanian Institute of Agriculture (UTAS/TIA)
 - Commonwealth Scientific and Industrial Research Organisation (CSIRO)
 
Activities were supported by a further 24 collaborating partners, overall encompassing 93 interacting research, technical and PhD candidate positions.
Forty-five field sites were used in the research effort, from Darwin in the north to Hobart in the south, supported by laboratory experimentation, analysis and systems modelling. The research has delivered or informed new N fertiliser formulations, application and measurement technologies, decision support tools and best management practice guidelines. 
MPfN continuously produced progressive outputs that were embedded into industry programs, reducing lag time between research and adoption by cotton, sugar, horticultural and dairy producers.  Over the Program’s duration, 173 extension activities were conducted that engaged with over 16,000 farmers, service providers and commercial advisors, as well as national and international researchers. These included industry and science conferences, field days, training workshops and webinars. 165 communication campaigns reached 478,000 people, through industry articles, videos, podcasts, websites and social media. Project materials developed included peer reviewed journal articles, industry best management practice (BMP) guidelines, economic case studies and decision trees/calculators totaling 84 outputs. Importantly, the teams of the MPfN Program conducted or participated in 77 collaboration activities with over 1500 other industry, research and commercial stakeholders, to ensure relevance, efficient delivery and consideration of aligned research.  
In June 2021, the MPfN Program delivered the final technologies and decision support resources that will significantly contribute to increased industry NUE in coming years.  As the outputs and outcomes of the research effort are extended through industry programs, it is anticipated that farmer uptake and adoption of recommendations and guidelines will gain momentum.  
The MPfN Program legacy promises to be a significant reduction in environmental impact from nitrogenous fertiliser use whilst delivering greater sustainability and profitability outcomes for Australian farming businesses.