Cotton leaf curl disease (CLCuD) causes serious losses to cotton production in many countries, such as India and Pakistan. For example, CLCuD cost the Pakistan industry about US$5 billion (1992-1997) and during the 2009-1010 season losses of 100% were seen in India. CLCuD is also present in Sudan, Egypt, Tanzania, Malawi, Nigeria and China. CLCuD is not present in Australia and represents a serious biosecurity risk.