Australian cotton production is characterised by high yielding, high quality cropping systems, earning in excess of $2.5b in export revenues annually. Crops are grown under an expanding scope of climatic conditions and diverse agronomic management practices, driven by broad industry use of transgenic technologies. Abiotic stressors and their management are key drivers of lint quality and yield. Australian cotton production systems are predominantly driven by water availability and the compounding impact of deficit on other system constraints. A key industry challenge is to minimise such climate-induced year to year production variability and maintain existing lint quality repute. An industry-led strategic imperative also exists to significantly increase productivity and profitability on cotton farms within 5 years, being partly achieved through both optimising cotton farming systems and protecting them from biotic threats and environmental stresses. This project aimed to address these strategic requisites by increasing crucial independent research capacity and capabilities for applied cotton systems research. The project aimed to investigate responsive agronomic practices for irrigated, rain-fed and abiotically stressed crops by leveraging plant growth regulator chemistry and applying modern sensing technologies and data analytics. This project continued research into the use of crop growth regulators seeking to modify or support crop growth to assist development of novel agronomic approaches to improve production resilience.