We have carried out one season of experiments on plant growth regulators that have not been used commercially in the Australian industry before (Glycinebetaine, Gibberellic acid and PGR TV) and compared these to Pix. These novel plant growth regulators may provide an important tool in improving fruit retention in cotton. Further, other important gains in efficiency may occur with the use of these regulators. These include the possible setting of fruit at lower node positions, which in turn may improve earliness, reduce late season insect control costs and reduce late season water applications.