Balanced fertilisation of major plant nutrients, nitrogen, phosphorus and potassium is a prerequisite for optimum growth and development of any crop including cotton. Interaction between nitrogen and phosphorus has been reported widely. For example, increasing level of N might influence the efficiency and uptake of P, and vice-versa. Similarly, optimum potassium nutrition for boll retention and boll loading is critical for cotton. Although Hearn (1975) and S. Yeats (1997; personal communication) conducted field experiments for optimising N levels, there has been no work involving all the three major nutrients for cotton production in the Ord. Our work reports results from a preliminary study conducted in 1999 on yield and quality of cotton in response to N, P and K fertilisation