Changes to the cotton farming system over the last decade have caused a change in the weed spectrum, favouring glyphosate tolerant, smallseeded, biannual and perennial weeds. Management of these weeds in a minimum tillage system relying increasingly on glyphosate is problematic. Adoption of a proactive, integrated weed management system that focuses on reducing the weed seed bank by using a variety of tools will be necessary to maintain the system and ensure the future value of glyphosate in the farming system.