Integrated Pest Management (IPM) in cotton emphasises conservation of beneficial species (mainly insects and spiders) to suppress pest populations and reduce the need to apply insecticides.

In 2010-2011 some 96% of the strains tested showed some level of neonicotinoid resistance (ie Actara-Cruiser or Shield) but that had fallen to 29% of cotton strains in season 2011-2012 and a similar 33% of cotton aphi

The resilience of a stacked Bt technology is determined by the efficacy of each individual toxin in controlling insects.

Solenopsis mealybug is an emerging pest of cotton in Australia.

The advent of Bt-cotton led to a dramatic decline in insecticide use against Helicoverpa spp. in the Australian cotton industry.